Search on: NIMA INTERACTING PEPTIDYLPROLYL ISOMERASE 
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Descriptor English:   NIMA-Interacting Peptidylprolyl Isomerase 
Descriptor Spanish:   Peptidilprolil Isomerasa de Interacción con NIMA 
Descriptor Portuguese:   Peptidilprolil Isomerase de Interação com NIMA 
Synonyms English:   Isomerase, NIMA-Interacting Peptidylprolyl
Isomerase, Pin1 Peptidylprolyl
NIMA Interacting Peptidylprolyl Isomerase
PIN1 Protein
Peptidyl Prolyl Cis Trans Isomerase Pin1
Peptidyl-Prolyl Cis-Trans Isomerase Pin1
Peptidylprolyl Isomerase, NIMA-Interacting
Peptidylprolyl Isomerase, Pin1
Pin1 Peptidylprolyl Isomerase  
Tree Number:   D08.811.399.325.500.700
Definition English:   A highly-conserved peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated SERINE- or THREONINE-PROLINE (pSer/Thr-Pro) motifs and causes conformational changes in certain proteins associated with the CELL CYCLE. It displays a preference for an acidic residue N-terminal to the isomerized proline bond and regulates MITOSIS, possibly by attenuating the mitosis-promoting activity of NIMA-RELATED KINASE 1. 
History Note English:   2017 (1996) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   56495 
Unique Identifier:   D000072340 

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